Convenient on water synthesis of novel derivatives of dicoumarol as functional vitamin K depleter by Fe3O4 magnetic nanoparticles

The Fe3O4 nanoparticles were successfully prepared and characterized by X-ray diffraction (XRD), Fourier transform-infrared (FT-IR), and transmission electron microscopy (TEM). The magnetic property of the prepared nanoparticles was investigated by magnetization analysis and the measured magnetization of NPs was found to be considerably lower than the values measured from bulk magnetite. The catalytic efficiency of the prepared nanoparticles was subsequently investigated as a magnetically recyclable and safe catalyst for the green synthesis of new dicoumarols via the one-pot condensation of 4-hydroxycoumarin with aryl glyoxals on water. Catalyst loadings can be as low as 2mol% to give good yields of the corresponding products. This present method has many advantages, such as the high product yield, avoidance of toxic organic solvents, and simple work-up procedure.