Hyperbaric Oxygen‐Facilitated Cancer Treatment: A Minireview

Hypoxia in malignant tumors is a major factor in inducing the failure of clinical cancer treatment. Although several strategies have been developed to relieve hypoxia, most are still in the preclinical research phase. Therefore, hyperbaric oxygen (HBO), an approved adjuvant therapy for alleviating hypoxia clinically, is an excellent choice for enhancing the efficacy of cancer treatment that is impeded by tumor hypoxia. In this minireview, recent advances in HBO‐facilitated cancer treatment, including clinical applications and nanomedicine‐mediated cancer therapy are introduced. At the end of this minireview, the potential challenges faced by HBO therapy before clinical use are discussed. It is hoped that this review will provide a reference for future clinical research on the application of HBO in cancer treatment. As a clinical adjuvant for alleviating hypoxia, hyperbaric oxygen (HBO) is an excellent choice to enhance the efficacy of cancer treatment. In this minireview, recent advances in HBO, including clinical and preclinical applications in chemotherapy, chemodynamic therapy, phototherapy, and immunotherapy, are summarized, and the current challenges and future research directions for HBO‐mediated cancer treatment are proposed.