POSSIBLE INTERRELATION BETWEEN PHOSPHOROUS DEFICIENCY AND VITAMIN D IN BUFFALOES (BUBALUS BUBALIS)

This investigation was conducted to appraise the interrelation between the influences of phosphorus deficiency on vitamin D and parathyroid hormone and assessment its effect on the liver and muscular markers. These investigations were carried on forty adult female water buffaloes divided into three groups according to serum phosphorus level. The first group contained ten apparently clinically healthy buffaloes and used as a control. The second and third groups were fifteen buffaloes for each suffered from moderate or severe signs of phosphorus deficiency (signs include anorexia, emaciation, weakness and paleness mucous membranes in the two groups in addition to red urine in the third one). Phosphorus level showed a significant decline in sub-clinical cases and highly significant decrease in clinical cases. Parathyroid hormone was significantly decline in sub-clinical and clinical cases, while active form of vitamin D wasn’t changed in sub-clinical cases and significantly decline in clinical cases when compared with normal control. Creatine phosphokinase significantly rise in clinical cases. Malondialdehyde was significantly increased while glutathione peroxidase was significantly decreased in both moderate and severe cases. This conclude that phosphorous deficiency causes lessening in parathyroid hormone, 25 hydroxycholecalciferol (25 (OH2) D3 and increasing in the markers of oxidative stress and muscular damage which exaggerated by increasing in the deficiency. So, addition of vitamin D supplementation and antioxidant should be conservative treatment regime.