Nanotechnology-Enabled COVID-19 mRNA Vaccines

Nanotechnology-Enabled COVID-19 mRNA Vaccines

COVID-19 mRNA vaccines contain synthetic mRNA sequences encoded for the Spike proteins expressed on the surface of SARS-CoV-2, and utilize the host cells to produce specific antigens that stimulate both humoral and cellular immunities. Lipid nanoparticles are essential to facilitate the intracellula...

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Veröffentlicht in:Encyclopedia (Basel, Switzerland) Switzerland), 2021-08, Vol.1 (3), p.773-780
Hauptverfasser: Gao, Yu, Yang, Kaiyun, Shelling, Andrew N., Wu, Zimei
Format: Artikel
Sprache:eng
Schlagworte:
Anaphylaxis
Antibodies
Antigens
Coronaviruses
COVID-19
COVID-19 vaccines
endosome escape
Infectious diseases
Innovations
intracellular delivery
lipid nanoparticles
Lipids
Lymphocytes
mRNA vaccine
mRNA vaccines
Nanoparticles
Nanotechnology
Pandemics
Polyethylene glycol
Proteins
Severe acute respiratory syndrome coronavirus 2
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Beschreibung
Zusammenfassung:COVID-19 mRNA vaccines contain synthetic mRNA sequences encoded for the Spike proteins expressed on the surface of SARS-CoV-2, and utilize the host cells to produce specific antigens that stimulate both humoral and cellular immunities. Lipid nanoparticles are essential to facilitate the intracellular delivery of the mRNA to its action site, the ribosome, to fully exert its effect.
ISSN:2673-8392
2673-8392
DOI:10.3390/encyclopedia1030059