New Triterpenoids from the Leaves of Heritiera littoralis and Their Anti-Inflammatory Activity

Six new triterpenoids, heritieras C-H ( - ), along with thirteen known triterpenoids ( - ), were isolated from the leaves of . Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with the literature. Anti-inflammatory activity of the isolates was evaluated using the lipopolysaccharide (LPS) stimulated RAW 264.7 cell model. Among the isolated triterpenoid, compounds , , , , and demonstrated inhibitory activity against nitric oxide (NO) release, in which compound exhibited the best activity with an IC value of 18.13 μM. The potential anti-inflammatory mechanism was investigated using molecular docking. The triterpenoids from could be served as potential candidates for the development of new anti-inflammatory agents.