P1.33 Predictors of Arterial Markers in Metabolic Syndrome Patients: Arterial Hypertension and Gender Outbid Dyslipidemia

Background and aim Metabolic syndrome (MetS) patients are at increased cardiovascular risk, but the exact mediation of the risk remains a matter of controversy. Various clusters of the metabolic syndrome components and other risk factors, such as advanced glycation end-products (AGE) and glycated hemoglobin (HbA1c), are considered, but large-scale studies are lacking. Therefore we aimed to investigate predictive value of MetS components and other factors on the arterial markers as a surrogate endpoint of cardiovascular risk. Methods A cross-sectional study of 3168 MetS subjects (aged 55±5, 69% women) was carried out by assessing various traditional and nontraditional cardiovascular risk factors and variety of arterial markers: intima media thickness (IMT), carotid, radial-femoral and aortic stiffness, ankle-brachial stiffness index (CAVI), endothelial function in brachial artery, finger and skin. Results The most common determinants of arterial markers by multiple linear and logistic regression analysis (p