5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal

5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal

Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat vi...

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Veröffentlicht in:Journal of Pharmacological Sciences 2011, Vol.117(2), pp.121-124
Hauptverfasser: Ohmura, Yu, Jutkiewicz, Emily M., Yoshioka, Mitsuhiro, Domino, Edward F.
Format: Artikel
Sprache:eng
Schlagworte:
5-Hydroxytryptophan - therapeutic use
addiction
Animals
Aromatic Amino Acid Decarboxylase Inhibitors
Behavior, Animal - drug effects
Hydrazines - pharmacology
Male
Nicotine - pharmacology
Rats
Rats, Sprague-Dawley
Serotonin Agents - therapeutic use
smoking
Smoking Cessation
Substance Withdrawal Syndrome - drug therapy
tobacco
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Zusammenfassung:Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting l-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT.
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.11074SC