Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI

Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI

The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the c...

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Veröffentlicht in:Journal of pharmaceutical analysis 2012-04, Vol.2 (2), p.90-97
Hauptverfasser: Palou, Anna, Cruz, Jordi, Blanco, Marcelo, Tomàs, Jaume, de los Ríos, Joaquín, Alcalà, Manel
Format: Artikel
Sprache:eng
Schlagworte:
Component distribution
Hyperspectral imaging
Near infrared Chemical Imaging (NIR-CI)
Partial Least Squares (PLS) regression
Tablet coating distribution
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Zusammenfassung:The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NI...
ISSN:2095-1779
2214-0883
DOI:10.1016/j.jpha.2011.11.003