Renal replacement therapy and concurrent fluconazole therapy increase linezolid-related thrombocytopenia among adult patients

Linezolid has been reported to be associated with thrombocytopenia. However, limited information is available on susceptibility to thrombocytopenia after linezolid usage. We aimed to investigate the risk factors for linezolid-associated thrombocytopenia (LAT). We conducted a retrospective cohort stu...

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Veröffentlicht in:	Scientific reports 2022-06, Vol.12 (1), p.9894-9894, Article 9894
Hauptverfasser:	Hsu, Yueh-Chun, Chen, Szu-Ying, Hung, Yung-Jun, Huang, Yu-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	692/499 692/700/565/1436/2774 692/700/565/2194 Antifungal agents Electronic medical records Fluconazole Humanities and Social Sciences Linezolid multidisciplinary Patients Platelets Renal replacement therapy Risk factors Science Science (multidisciplinary) Thrombocytopenia
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Zusammenfassung:	Linezolid has been reported to be associated with thrombocytopenia. However, limited information is available on susceptibility to thrombocytopenia after linezolid usage. We aimed to investigate the risk factors for linezolid-associated thrombocytopenia (LAT). We conducted a retrospective cohort study of patients aged ≥ 18 years who received linezolid for ≥ 5 d during hospitalization in 2019. Information was extracted from electronic medical records. Thrombocytopenia was defined as a platelet count of
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-13874-y