Five New Terpenes with Cytotoxic Activity from Pestalotiopsis sp

Five new compounds called Pestalotis A-E ( - ), comprising three monoterpene-lactone compounds ( - ), one tetrahydrobenzofuran derivative ( ), and one sesquiterpene ( ), were isolated from the EtOAc extract of sp. The structures of the new compounds were elucidated by analysis of their NMR, HRMS, an...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-11, Vol.26 (23), p.7229
Hauptverfasser:	Zhao, Dan, Hu, Meigeng, Ma, Guoxu, Xu, Xudong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Carbon Carbon-13 Magnetic Resonance Spectroscopy Cell Death - drug effects Cell Line, Tumor Cell lines cytotoxic activities Cytotoxicity HuH-7 cell lines Humans Ligusticum chuanxiong lung cancer Metabolites NMR Nuclear magnetic resonance Pestalotiopsis Pestalotiopsis - chemistry Proton Magnetic Resonance Spectroscopy terpenes Terpenes - chemistry Terpenes - pharmacology
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Beschreibung
Zusammenfassung:	Five new compounds called Pestalotis A-E ( - ), comprising three monoterpene-lactone compounds ( - ), one tetrahydrobenzofuran derivative ( ), and one sesquiterpene ( ), were isolated from the EtOAc extract of sp. The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. All compounds were tested for antitumor activity against SW-480, LoVo, HuH-7, and MCF-7. The results showed that compounds and exhibited potent antitumor activity against SW-480, LoVo, and HuH-7 cell lines. Furthermore, compound was assessed against HuH-7, and the results indicated that the rate of apoptosis was dose-dependent.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26237229