The protective roles of tea tree oil extracts in bovine mammary epithelial cells and polymorphonuclear leukocytes

Tea tree oil (TTO) plays an important role in antibacterial activity and alleviating the inflammatory responses. Bovine mammary epithelium and polymorphonuclear leukocytes (PMNL) can actively respond to bovine mastitis infection. However, regulatory effects of TTO extracts on the innate immune respo...

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Veröffentlicht in:	Journal of Animal Science and Biotechnology 2020-06, Vol.11 (1), p.62-62, Article 62
Hauptverfasser:	Zhan, Kang, Yang, Tianyu, Feng, Baobao, Zhu, Xinyu, Chen, Yinyin, Huo, Yongjiu, Zhao, Guoqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial activity Antibiotics Biofilms Bovine mammary epithelial cells Cattle Cytokines Epithelial cells Epithelium Essential oils Granulocytes Health aspects IL-1β Immune response Immune system Infection Inflammation Inflammatory response Innate immunity Interleukin 6 Interleukin 8 Investigations Leukocyte migration Leukocytes Leukocytes (polymorphonuclear) Mammary gland Mastitis Melaleuca alternifolia Methicillin mRNA NF-κB protein Oils & fats Pathogens PMNL RNA Staphylococcus aureus Staphylococcus infections Tea tree oil Tumor necrosis factor-α
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Zusammenfassung:	Tea tree oil (TTO) plays an important role in antibacterial activity and alleviating the inflammatory responses. Bovine mammary epithelium and polymorphonuclear leukocytes (PMNL) can actively respond to bovine mastitis infection. However, regulatory effects of TTO extracts on the innate immune response of bovine mammary epithelial cells (BMECs) and PMNL remain not reported. Therefore, aim of the study was to evaluate the effects of TTO extracts on the mRNA levels of the genes involved in the innate immune response of BMECs and PMNL. Our results demonstrated that addition of 0.025% and 0.05% TTO increased the proliferation of BMECs, and significantly enhanced (
ISSN:	1674-9782 2049-1891 2049-1891
DOI:	10.1186/s40104-020-00468-9