New terpenes from the Egyptian soft coral Sarcophyton ehrenbergi

Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1-3 as well as the previously reported marine cembranoid diterpene sarcophine (4). Structures were elucidated by comprehensive NMR and HRMS experimentation. Isolated compounds were in vit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Marine drugs 2014-04, Vol.12 (4), p.1977-1986
Hauptverfasser:	Elkhateeb, Ahmed, El-Beih, Ahmed A, Gamal-Eldeen, Amira M, Alhammady, Montaser A, Ohta, Shinji, Paré, Paul W, Hegazy, Mohamed-Elamir F
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - isolation & purification 4-Butyrolactone - pharmacology Adenocarcinoma - drug therapy Animals Anthozoa - metabolism Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Carcinoma, Hepatocellular - drug therapy cembranoids cytotoxic activity Egypt Hep G2 Cells Humans Liver Neoplasms - drug therapy Magnetic Resonance Spectroscopy Marine MCF-7 Cells Sarcophyton ehrenbergi sesquiterpenes soft coral terpenes Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1-3 as well as the previously reported marine cembranoid diterpene sarcophine (4). Structures were elucidated by comprehensive NMR and HRMS experimentation. Isolated compounds were in vitro assayed for cytotoxic activity against human hepatocarcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md12041977