Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants

Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of -acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. Th...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-08, Vol.26 (16), p.4892
Hauptverfasser:	Cozma, Vlad, Rosca, Irina, Radulescu, Luminita, Martu, Cristian, Nastasa, Valentin, Varganici, Cristian-Dragos, Ursu, Elena-Laura, Doroftei, Florica, Pinteala, Mariana, Racles, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - chemistry Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibacterial Antiinfectives and antibacterials Bacterial Adhesion - drug effects Biocompatibility Biofilms Biofilms - drug effects Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Coated Materials, Biocompatible - therapeutic use Cochlea Cochlear implants Cochlear Implants - adverse effects Cochlear Implants - microbiology Crosslinking Deafness Drug resistance Hearing aids Hearing loss In vitro methods and tests Medical equipment Membranes Microorganisms N-acetyl- l -cysteine Otitis - drug therapy Polymers Polymers - chemistry Polymers - pharmacology Polymers - therapeutic use Polysiloxanes Rats Rats, Wistar Silicones Siloxanes - chemistry Siloxanes - pharmacology Siloxanes - therapeutic use Spectrum analysis Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Sulfhydryl Compounds - chemistry Surface Properties Titanium alloys Transplants & implants
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Beschreibung
Zusammenfassung:	Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of -acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. These membranes were subjected to in vitro testing for microbial adherence against using standardized tests. WISTAR rats were implanted for 4 weeks with crosslinked siloxane samples without and with NAC. A set of physical characterization methods was employed to assess the chemical structure and morphological aspects of the new synthetized materials before and after contact with the microbiological medium.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26164892