SE EFFECT ON BIOLOGICAL ACTIVITY OF FLAMMULINA VELUTIPES

The goals of the study were evaluation of antioxidant, antifungal and anticancer potential of Flammulina velutipes mycelium ethanol extract and examination of Se effect on those activities. Both Se-amended and non-amended mycelium extracts exhibited significant antioxidant and antifungal potential. Se-enriched extract was more effective against Candida krusei and C. albicans and better DPPH* scavengers than non enriched one. Carriers of the antioxidant activity were phenol compounds. Contrary to antioxidant and antifungal potential, tested extracts were many times weaker cytotoxic agents against HeLa and LS174 cell lines than cis-DDP Thus, Se- enriched mycelium could be supplement with antioxidant and antifungal capacity. --Keywords: anticancer activity, antifungal activity, antioxidant activity, Flammulina velutipes, Se-enriched mycelium