Thiazole formation through a modified Gewald reaction

Thiazole formation through a modified Gewald reaction

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the su...

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Veröffentlicht in:Beilstein journal of organic chemistry 2015-05, Vol.11 (1), p.875-883
Hauptverfasser: Mallia, Carl J, Englert, Lukas, Walter, Gary C, Baxendale, Ian R
Format: Artikel
Sprache:eng
Schlagworte:
1,4-dithiane-2,5-diol
Chemistry
design of experiment (DOE)
Full Research Paper
Gewald reaction
thiazole
thiophene
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Beschreibung
Zusammenfassung:The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.11.98