Significance of Schistosomal Granuloma Modulation
Hepatic Schistosoma mansoni periovular granulomas undergo changes in size, cellular composition and appearance with time. This phenomenom, known as "immunological modulation", has been thought to reflect host immunological status. However, as modulation has not been observed outside the li...
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Veröffentlicht in: | Memórias do Instituto Oswaldo Cruz 2000-06, Vol.95 (3), p.353-361 |
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Zusammenfassung: | Hepatic Schistosoma mansoni periovular granulomas undergo changes in
size, cellular composition and appearance with time. This phenomenom,
known as "immunological modulation", has been thought to reflect host
immunological status. However, as modulation has not been observed
outside the liver, participation of local factors, hitherto little
considered, seems crucial. Components of the extracellular matrix of
periovular granulomas of the mouse were particularly studied in three
different organs (liver, lung and intestine) and during three periods
of infection time (acute, intermediate and chronic) by means of
histological, biochemical and imunofluorescence techniques, while
quantitative data were evaluated by computerized morphometry, in order
to investigate participation of local factors in granuloma modulation.
Results confirmed modulation as a exclusively hepatic phenomenom, since
pulmonary and intestinal granulomas, formed around mature eggs, did not
change size and appearance with time. The matricial components which
were investigated (Type I, III and IV collagens, fibronectin, laminin,
proteoglycans and elastin) were found in all granulomas and in all
organs examined. However, their presence was much more prominent in the
liver. Elastin was only found in hepatic granulomas of chronic
infection. The large amount of extracellular matrix components found in
hepatic granulomas was the main change responsible for the
morphological aspects of modulation. Therefore, the peculiar
environment of the liver ultimately determines the changes identified
in schistosomal granuloma as "modulation". |
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ISSN: | 1678-8060 0074-0276 0074-0276 1678-8060 |
DOI: | 10.1590/S0074-02762000000300010 |