Effect of low vs. high vancomycin trough level on the clinical outcomes of adult patients with sepsis or gram-positive bacterial infections: a systematic review and meta-analysis

The Infectious Disease Society of America guidelines recommend vancomycin trough levels of 15-20 mg/L for severe methicillin-resistant Staphylococcus aureus. However, recent consensus guidelines of four infectious disease organizations no longer recommend vancomycin dosing using minimum serum trough...

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Veröffentlicht in:	BMC infectious diseases 2024-10, Vol.24 (1), p.1114-16, Article 1114
Hauptverfasser:	Chander, Subhash, Kumari, Roopa, Wang, Hong Yu, Mohammed, Yaqub Nadeem, Parkash, Om, Lohana, Sindhu, Sorath, Fnu, Lohana, Abhi Chand, Sadarat, Fnu, Shiwlani, Sheena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Bacteria Bacterial diseases Bacterial infections Clinical outcomes Complications and side effects Drug dosages Drug resistance Drug therapy Failure Gram-positive bacteria Gram-positive bacterial infections Gram-Positive Bacterial Infections - blood Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - mortality Guidelines Health services Humans Infection Infectious diseases Length of Stay - statistics & numerical data Literature reviews Meta-analysis Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Microorganisms Mortality MRSA Online databases Patient outcomes Patients Risk management Sepsis Sepsis - drug therapy Sepsis - microbiology Sepsis - mortality Septic shock Septic shock patients Staphylococcus aureus Staphylococcus aureus infections Staphylococcus infections Systematic Review Treatment Outcome Trough levels Vancomycin Vancomycin - administration & dosage Vancomycin - blood Vancomycin - pharmacokinetics Vancomycin - therapeutic use
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Zusammenfassung:	The Infectious Disease Society of America guidelines recommend vancomycin trough levels of 15-20 mg/L for severe methicillin-resistant Staphylococcus aureus. However, recent consensus guidelines of four infectious disease organizations no longer recommend vancomycin dosing using minimum serum trough concentrations. Therefore, this study aimed to evaluate the impact of low (
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-024-09927-4