Mitochondrial Control in Inflammatory Gastrointestinal Diseases

Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of mu...

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Veröffentlicht in:	International journal of molecular sciences 2022-11, Vol.23 (23), p.14890
Hauptverfasser:	Sui, Guo-Yan, Wang, Feng, Lee, Jin, Roh, Yoon Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy biogenesis Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Endoplasmic reticulum Gastrointestinal diseases Gastrointestinal system Genomes Homeostasis Humans Immune system Inflammation inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - metabolism Inflammatory diseases Kinases Metabolism Metabolites Mitochondria Mitochondria - metabolism Mitochondrial DNA mitophagy Mutation Phosphorylation Physiology Proteins Quality control Review Signal Transduction Tumor necrosis factor-TNF
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Beschreibung
Zusammenfassung:	Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms232314890