Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity

Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical applications, nanovectors-assisted gene deliv...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-02, Vol.25 (4), p.1003
Hauptverfasser:	Marson, Domenico, Laurini, Erik, Aulic, Suzana, Fermeglia, Maurizio, Pricl, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	amphiphilic ligands Anticoagulants Binding sites Biomedical materials Cell cycle Cell membranes chirality Deoxyribonucleic acid DNA DNA - chemistry Gene transfer Heparin Heparin - chemistry Hydrophobic and Hydrophilic Interactions isothermal titration calorimetry Kinases Ligands Membranes Methylamines - chemistry Micelles Molecular Dynamics Simulation molecular simulations multivalency Nanostructures - chemistry Nucleic acids Physiology Polyamines polyanion binding Polyanions Polyelectrolytes Polymers - chemistry Polysaccharides Recognition Review Saccharides Selectivity Self-assembly Solutions Spermidine - chemistry Spermine - chemistry Surface-Active Agents - chemistry Thermodynamics Trends
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Zusammenfassung:	Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical applications, nanovectors-assisted gene delivery being a prime example. This review work summarizes some of our recent efforts in this field; in particular, by using a combined experimental/computation approach, we investigated in detail some critical aspects in self-assembled nanomicelles and two major polyanions-DNA and heparin.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25041003