Departure from Hardy Weinberg Equilibrium and Genotyping Error

Departure from Hardy Weinberg Equilibrium (HWE) may occur due to a variety of causes, including purifying selection, inbreeding, population substructure, copy number variation or genotyping error. We searched for specific characteristics of HWE-departure due to genotyping error. Genotypes of a rando...

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Veröffentlicht in:	Frontiers in genetics 2017-10, Vol.8, p.167-167
Hauptverfasser:	Chen, Bowang, Cole, John W, Grond-Ginsbach, Caspar
Format:	Artikel
Sprache:	eng
Schlagworte:	association studies in genetics Genetics Hardy Weinberg Equilibrium (HWE) heterozygosity SNP quality control
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Zusammenfassung:	Departure from Hardy Weinberg Equilibrium (HWE) may occur due to a variety of causes, including purifying selection, inbreeding, population substructure, copy number variation or genotyping error. We searched for specific characteristics of HWE-departure due to genotyping error. Genotypes of a random set of genetic variants were obtained from the Exome Aggregation Consortium (ExAC) database. Variants with
ISSN:	1664-8021 1664-8021
DOI:	10.3389/fgene.2017.00167