Comparing the Effects of Rosemary Extract and Treadmill Exercise on the Hippocampal Function and Antioxidant Capacity in Old Rats

Comparing the Effects of Rosemary Extract and Treadmill Exercise on the Hippocampal Function and Antioxidant Capacity in Old Rats

A sequence of time-dependent changes can affect the brain's functional capacity.This study aimed at investigating the effects of Forced Aerobic Exercise (FAE) versus the Rosemary Extract (RE) on the learning abilities and oxidative stress modulation in rats. Young and old rats received daily FA...

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Veröffentlicht in:Basic and clinical neuroscience 2021-05, Vol.12 (3), p.361-372
Hauptverfasser: Rasoolijazi, Homa, Norouzi Ofogh, Sattar, Ababzadeh, Shima, Mehdizadeh, Mehdi, Shabkhiz, Fatemeh
Format: Artikel
Sprache:eng
Schlagworte:
Aerobic capacity
aerobic exercise
aging
antiox idant
Antioxidants
cognition
Enzymatic activity
Enzymes
Exercise
Glutathione peroxidase
Hippocampus
Latency
Learning
Oxidative stress
Research Paper
Short term memory
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Zusammenfassung:A sequence of time-dependent changes can affect the brain's functional capacity.This study aimed at investigating the effects of Forced Aerobic Exercise (FAE) versus the Rosemary Extract (RE) on the learning abilities and oxidative stress modulation in rats. Young and old rats received daily FAE and RE for 3 months. Using the Passive Avoidance (PA) test, we evaluated the learning and memory of the rats by Step-Through Latency (STL) score. We measured the Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CATA), Malondialdehyde (MDA) enzymes levels, and Total Antioxidant Capacity (TAC) in the hippocampus. FAE could significantly increase the STL score (P
ISSN:2008-126X
2228-7442
2228-7442
DOI:10.32598/bcn.12.3.2139.1