Outcomes of severely ill patients with AIDS treated with efavirenz or dolutegravir: a multicenter, observational study

Outcomes of severely ill patients with AIDS treated with efavirenz or dolutegravir: a multicenter, observational study

Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV). To compare the effect of DTG- or efavirenz (EFV)-based regimens on the outc...

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Veröffentlicht in:Frontiers in medicine 2024-02, Vol.11, p.1302710-1302710
Hauptverfasser: Brites, Carlos, Lacerda, Marcus, Sprinz, Eduardo, Bay, Monica, Pinto, Gustavo, Azevedo, Pollyanna, Luz, Estela, Lins-Kusterer, Liliane, Netto, Eduardo M
Format: Artikel
Sprache:eng
Schlagworte:
advanced AIDS
adverse (side) effects
dolutegravir
early mortality
efavirenz
Medicine
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Zusammenfassung:Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV). To compare the effect of DTG- or efavirenz (EFV)-based regimens on the outcomes of patients with advanced AIDS. We compared two cohorts of consecutive symptomatic AIDS patients (WHO stage 4, CD4 count
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2024.1302710