Current Knowledge of the Potential Links between Inflammation and Prostate Cancer

Inflammation is inherent in prostatic diseases and it is now accepted that it may facilitate cellular proliferation in both benign and malignant conditions. The strong relationship between prostatic inflammation and pathogenesis of benign prostatic hyperplasia (BPH) is supported by epidemiologic, hi...

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Veröffentlicht in:International journal of molecular sciences 2019-08, Vol.20 (15), p.3833
Hauptverfasser: Cai, Tommaso, Santi, Raffaella, Tamanini, Irene, Galli, Ilaria Camilla, Perletti, Gianpaolo, Bjerklund Johansen, Truls E, Nesi, Gabriella
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Sprache:eng
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Zusammenfassung:Inflammation is inherent in prostatic diseases and it is now accepted that it may facilitate cellular proliferation in both benign and malignant conditions. The strong relationship between prostatic inflammation and pathogenesis of benign prostatic hyperplasia (BPH) is supported by epidemiologic, histopathologic and molecular evidence. Contrariwise, the role of inflammation in prostate carcinogenesis is still controversial, although current data indicate that the inflammatory microenvironment can regulate prostate cancer (PCa) growth and progression. Knowledge of the complex molecular landscape associated with chronic inflammation in the context of PCa may lead to the introduction and optimization of novel targeted therapies. In this perspective, evaluation of the inflammatory component in prostate specimens could be included in routine pathology reports.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20153833