Clinicopathological features of inflammatory demyelinating diseases in biopsy

[4] Of the 23 patients examined, 15 exhibited lesions that were classified as active and early demyelinating lesions, six exhibited lesions that were classified as active and late demyelinating lesions, and two exhibited lesions that were classified as active and post-demyelinating lesions. [...]the lesions in the small biopsies in this study were all active lesions, and no chronic inactive demyelinating lesions, which are commonly observed in autopsy specimens, were found. [...]axons were also necrotic in ischemic cerebral infarction. [...]we can differentiate cerebral infarction and IDD by combining clinical manifestations with IHC staining for NF since axons in cerebral infarction lesions are absent while axons in IDD are relatively preserved. [...]we demonstrated that to make a pathological diagnosis of IDD in biopsy, the clinical manifestations, MRI and pathological morphology should be combined for comprehensive analysis.