Serum Neuron-Specific Enolase as a Biomarker of Neonatal Brain Injury-New Perspectives for the Identification of Preterm Neonates at High Risk for Severe Intraventricular Hemorrhage

Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 day...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2024-04, Vol.14 (4), p.434
Hauptverfasser:	Metallinou, Dimitra, Karampas, Grigorios, Pavlou, Maria-Loukia, Louma, Maria-Ioanna, Mantzou, Aimilia, Sarantaki, Antigoni, Nanou, Christina, Gourounti, Kleanthi, Tzeli, Maria, Pantelaki, Nikoletta, Tzamakos, Evangelos, Boutsikou, Theodora, Lykeridou, Aikaterini, Iacovidou, Nicoletta
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers - blood Birth weight Brain Brain Injuries - blood Brain Injuries - diagnosis Brain injury Brain research Case-Control Studies Cerebral Hemorrhage - blood Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - diagnostic imaging Cerebral Intraventricular Hemorrhage - blood Cerebral Intraventricular Hemorrhage - diagnostic imaging Enolase Evaluation Female Gestational Age Health aspects Hemorrhage Humans Hypoxia Infant, Newborn Infant, Premature - blood Infants (Newborn) Injuries Intensive care Intraventricular hemorrhage Ischemia Leukomalacia, Periventricular - blood Leukomalacia, Periventricular - diagnostic imaging Male Medical personnel Metabolism Neonates neuron-specific enolase Periventricular leukomalacia Phosphopyruvate hydratase Phosphopyruvate Hydratase - blood Physiological aspects preterm neonate Professional ethics Prognosis Prospective Studies Risk factors serum Statistical analysis Traumatic brain injury Variance analysis
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Beschreibung
Zusammenfassung:	Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 days of life in preterm neonates (
ISSN:	2218-273X 2218-273X
DOI:	10.3390/biom14040434