Anaphylaxis case report to trimethylphloroglucinol (Spasfon®)

[Dear Editor, ] Phloroglucinol (P) and its methylated derivative (TMP) are both phenol derivative antispasmodic agents acting on smooth muscle and prescribed to treat acute spasmodic abdominal pain, acute painful disorders of the urinary tract, and acute pain in gynecology. It has been showed that P and TMP act by reducing glycerol-induced abdominal pain and by inhibiting colonic phasic contractions. Exceptionally, P and TMP are associated with muco-cutaneous manifestations and allergic reactions. It has been reported, in the French National pharmacovigilance database, 21 cases of anaphylaxis to phloroglucinol, including 16 cases of anaphylactic shock and 5 cases of allergic skin reaction (unpublished data). We report a case of anaphylaxis to phloroglucinol confirmed by skin testing. [Case report] We report the case of a 23 year old female patient, who has a medical history of mildly active ulcerative colitis treated with mesalamine (Pentasa(R)). She had no relevant past surgical history.