How to monitor thiopental administration in the intensive care unit for refectory status epilepticus or intracranial hypertension?

The subsequent reduction in the cerebral metabolic demand and blood flow also allows decreasing the intracranial pressure (ICP) [1]. [...]the suppression ratio (SR) provides a metric of the depth of sedation during general anesthesia [5]. Since the target of thiopental sedation is to reach a discontinuous EEG activity (i.e., SR ≥ 10%); the aim of the herein study was to evaluate the relationship between the thiopental concentration and the SR in patients with a refractory SE or IH. Winer JW, Rosenwasser RH, Jimenez F. Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma.