Synthesis and Biological Evaluations of a Novel Oxidovanadium(IV) Adenosine Monophosphate Complex as Anti-Diabetic Agent

Synthesis and Biological Evaluations of a Novel Oxidovanadium(IV) Adenosine Monophosphate Complex as Anti-Diabetic Agent

In the present study, a novel [(AMP)(VO)(H2O)2] complex was formed through chemical reactions between oxidovanadium(IV)sulfate and adenosine monophosphate. This complex was characterized using various analyses, including microanalytical, molar conductivity, spectroscopic (solid reflectance and FTIR)...

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Veröffentlicht in:Crystals (Basel) 2019-04, Vol.9 (4), p.208
Hauptverfasser: Naglah, Ahmed, Al-Omar, Mohamed, Bhat, Mashooq, Al-Wasidi, Asma, Alsuhaibani, Amnah, El-Didamony, Akram, Hassan, Nader, Abo Taleb, Sameh, Refat, Moamen
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Adenosine monophosphate
Binding sites
Chemical reactions
Cholesterol
complex
Diabetes
Geometry
Hydrogen bonds
In vivo methods and tests
Insulin
Ligands
Liver
Magnetic permeability
metal ions
oxidovanadium(IV) sulfate
Pancreas
streptozotocin
Vibration
X ray powder diffraction
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Zusammenfassung:In the present study, a novel [(AMP)(VO)(H2O)2] complex was formed through chemical reactions between oxidovanadium(IV)sulfate and adenosine monophosphate. This complex was characterized using various analyses, including microanalytical, molar conductivity, spectroscopic (solid reflectance and FTIR), magnetic susceptibility, thermogravimetric (TGA), X-ray powder diffraction (XRD), and scanning (SEM) and transmission (TEM) electron microscopy. The in vivo antidiabetic activity of the oxidovanadium(IV) complex was determined using streptozotocin-induced rats. The results suggested that the synthesized complex can be used as an antidiabetic agent based on the observed biochemical effects.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst9040208