Children with developmental coordination disorder show altered functional connectivity compared to peers

•Functional connectivity in the sensorimotor network is altered in children with DCD.•Connectivity to posterior cingulate cortex and precuneus is impaired in DCD.•Connectivity to middle posterior temporal gyrus is impaired in DCD.•Altered connectivity of sensorimotor network may explain motor problems in DCD. Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder that affects a child’s ability to learn motor skills and participate in self-care, educational, and leisure activities. The cause of DCD is unknown, but evidence suggests that children with DCD have atypical brain structure and function. Resting-state MRI assesses functional connectivity by identifying brain regions that have parallel activation during rest. As only a few studies have examined functional connectivity in this population, our objective was to compare whole-brain resting-state functional connectivity of children with DCD and typically-developing children. Using Independent Component Analysis (ICA), we compared functional connectivity of 8–12 year old children with DCD (N = 35) and typically-developing children (N = 23) across 19 networks, controlling for age and sex. Children with DCD demonstrate altered functional connectivity between the sensorimotor network and the posterior cingulate cortex (PCC), precuneus, and the posterior middle temporal gyrus (pMTG) (p