Genetic polymorphisms of glutathione S transferase and cervical intraepithelial neoplasia

The present study aim to analyze the relationship between GST M/T genotypes of glutathione S-transferases and cervical intraepithelial neoplasia. A prospective case-control study has been designed including 69 cases with different degrees of cervical dysplasia and 107 controls. All patients had been examined colposcopically. For every patient both cervical and blood specimen have been obtained. The peripheral blood was used for GST M/T genotyping. The statistical analysis was performed using OR and chi-square at a level of significance inferior to 0.05. No statistically significant differences had been found between cases and controls for GST T-/M- geno-type (T-/M-, χ =0.03, p= 0.8610) and T+/M+ χ =0.65, p = 0.4197. Patients with in situ carcinoma had significant GST genotype association for T-/M+ genotype (OR=4.66, CI 95% [0.6528,24.9725], χ =4.6, p=0.0314) and for T+/M- genotype (OR=0.12, CI 95% [0.0027,0.9465], χ =0.05, p=0.0219). The combination of GST genotypes can be included in a predictive score for patients with cervical carcinoma.