A new cycloartane-type triterpenoid saponin xanthine oxidase inhibitor from Homonoia riparia Lour

A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin h...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2014-08, Vol.19 (9), p.13422-13431
Hauptverfasser:	Xu, Fan, Zhao, Xueqian, Yang, Lingli, Wang, Xiuhua, Zhao, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Communication Crystallography Crystallography, X-Ray cycloartane-type triterpenoid saponin Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Euphorbiaceae - chemistry Homonoia riparia Lour Models, Molecular Molecular Conformation Saponins - chemistry Saponins - isolation & purification Spectrum analysis Triterpenes - chemistry Triterpenes - isolation & purification Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - chemistry xanthine oxidase inhibitors
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Beschreibung
Zusammenfassung:	A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin has a significant inhibitory effect on xanthine oxidase in vitro, and the IC50 was 11.16 nmol/mL.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules190913422