Screening of metabolic markers present in Oxytropis by UHPLC-Q-TOF/MS and preliminary pharmacophylogenetic investigation
Plants belonging to the Oxytropis genus, family Leguminosae, are found throughout the world, with about 80 species mainly distributed in northwest and northeast China. The plants have medicinal properties and many plants have been used as folk medicine for the treatment of colds, inflammation of car...
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Veröffentlicht in: | Frontiers in plant science 2022-10, Vol.13, p.958460-958460 |
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Zusammenfassung: | Plants belonging to the
Oxytropis
genus, family Leguminosae, are found throughout the world, with about 80 species mainly distributed in northwest and northeast China. The plants have medicinal properties and many plants have been used as folk medicine for the treatment of colds, inflammation of carbuncle swelling, pain, and different types of bleeding. In recent years, due to the reduced availability of wild resources and increased clinical demand, additional
Oxytropis
species have been used in Mongolian medicine. This study explored the medicinal potential of four
Oxytropis
species, investigating their phylogeny, chemical components, and pharmacological activities.
Oxytropis myriophylla
(Pall) DC.,
Oxytropis hirta
Bunge, and
Oxytropis bicolor
Bge. were found to be closely related at the taxonomic level. While previous investigations on the bioactive constituents of
Oxytropis
have been limited and have concentrated largely on flavonoids and saponins, the present study established a novel UHPLC-Q-TOF/MS based on metabolite profiling to comprehensively analyze the chemical composition of the four
Oxytropis
species and to identify marker compounds. A total of 75 compounds were identified from the four species, with 23 identified as characteristic marker components. Twenty-six marker compounds were identified in
O. myriophylla
from different geographical regions. Analysis of pharmacological activity showed that extracts of
O. myriophylla
and
O. hirta
had stronger anti-inflammatory activity than the extracts from the other species. The relationships between the chemical components, traditional curative uses, and pharmacological activities were analyzed to provide a preliminary documentation of the pharmacophylogenetic characteristics of the
Oxytropis
family as a whole. Several marker compounds, including licoricesaponin G2, licoricesaponin J2, and glycyrrhizic acid found in
O. hirta
were found to have effective anti-inflammatory activity, consistent with the traditional application of reducing swelling and healing wounds. This preliminary investigation into the pharmacophylogeny of the genus
Oxytropis
will contribute to the conservation and exploitation of the medicinal resources of this genus. |
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ISSN: | 1664-462X 1664-462X |
DOI: | 10.3389/fpls.2022.958460 |