A Perspective on Organoids for Virology Research

A Perspective on Organoids for Virology Research

Animal models and cell lines are invaluable for virology research and host-pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to...

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Veröffentlicht in:Viruses 2020-11, Vol.12 (11), p.1341
Hauptverfasser: Sridhar, Adithya, Simmini, Salvatore, Ribeiro, Carla M S, Tapparel, Caroline, Evers, Melvin M, Pajkrt, Dasja, Wolthers, Katja
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation
Animal models
Brain research
Cell culture
Cell lines
Cytomegalovirus
Disease
Heparan sulfate
Host-Pathogen Interactions
human organoids
Humans
Infections
Laboratories
Microcephaly
Models, Biological
Opinion
Organoids
Organoids - virology
Pathogenesis
Pathogens
standardization
Stem cells
Tissue Culture Techniques
Viral diseases
Viral infections
Virology
Virology - methods
Zika virus
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Beschreibung
Zusammenfassung:Animal models and cell lines are invaluable for virology research and host-pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.
ISSN:1999-4915
1999-4915
DOI:10.3390/v12111341