T-Natural Killers and Interferon Gamma/Interleukin 4 in Augmentation of Infection in Foot Ulcer in Type 2 Diabetes

The link between immune system and type 2 diabetes mellitus (T2DM) pathogenesis attracted attention to demonstrate the role of immune cells and their secreted cytokines in T2DM development and its subsequent foot complications. To investigate the relation between T Natural killer cell (TNK) %, Inter...

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Veröffentlicht in:	Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2021-01, Vol.14, p.1897-1908
Hauptverfasser:	Hammad, Reham, Elmadbouly, Asmaa A, Ahmad, Inass Hassan, Mohammed, Shaymaa A, Farouk, Nehal, Futooh, Zahraa, Alfy, Mohamed Omar, Abozaid, Sarah, Mohamed, Eman F, Kotb, Fatma M, Abdelbadea, Alzahra, Seliem, Nora, Elshafei, Ahmed, Mashaal, Alya
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Biological response modifiers Blood tests Cytokines Development and progression Diabetes Diabetic foot diabetic foot infection diabetic foot ulcer Diabetics Enzyme-linked immunosorbent assay Ethylenediaminetetraacetic acid Flow cytometry Foot diseases Glycosylated hemoglobin Health aspects Hemoglobin Infection Infections Interferon gamma interleukin 4 Interleukins Ischemia Killer cells Leg ulcers Lipids Low density lipoproteins Medical research Medicine, Experimental natural killer cell Original Research Outpatient care facilities Type 2 diabetes Variance analysis
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Zusammenfassung:	The link between immune system and type 2 diabetes mellitus (T2DM) pathogenesis attracted attention to demonstrate the role of immune cells and their secreted cytokines in T2DM development and its subsequent foot complications. To investigate the relation between T Natural killer cell (TNK) %, Interleukin 4 (IL4) and Interferon gamma (IFN-γ) and diabetic foot infection (DFI) development in patients with diabetic foot ulcer (DFU). Ninety patients with diabetes were included in this work, divided as T2DM group (n=30), DFU group (n=30), and DFI group (n=30). TNK% was detected using flow cytometry. Serum IL4 and IFN-γ were measured by ELISA. Diabetes biochemical parameters were also analyzed. Significant decrease was detected in TNK% and IFN-γ in DFI group compared to other 2 groups (
ISSN:	1178-7007 1178-7007
DOI:	10.2147/DMSO.S305511