The genetic regulation of protein expression in cerebrospinal fluid

Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 participants from the BioFINDER study. Protein quantitative trait loci (pQTL) were identified as associations between genetic...

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Veröffentlicht in:	EMBO molecular medicine 2023-01, Vol.15 (1), p.e16359-n/a
Hauptverfasser:	Hansson, Oskar, Kumar, Atul, Janelidze, Shorena, Stomrud, Erik, Insel, Philip S, Blennow, Kaj, Zetterberg, Henrik, Fauman, Eric, Hedman, Åsa K, Nagle, Michael W, Whelan, Christopher D, Baird, Denis, Mälarstig, Anders, Mattsson‐Carlgren, Niklas
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - genetics Alzheimer's disease Amyotrophic lateral sclerosis Antibodies Antigens, CD Apolipoprotein E Basic Medicine Biomarkers Biomarkers - cerebrospinal fluid CD38 antigen Cerebrospinal fluid Clinical Medicine Datasets Dementia Gene loci Genetic diversity genetic regulation Genomes Humans Klinisk medicin Magnetic resonance imaging Matrix Metalloproteinase 10 - genetics Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Membrane Glycoproteins - genetics Membrane Proteins - genetics Mendelian randomization Movement disorders Neurodegenerative diseases Neuroimaging Neurologi Neurological diseases Neurology Neurosciences Neurovetenskaper Parkinson Disease - genetics Parkinson's disease Plasma Plasma proteins pQTL Proteins Proteomes Proteomics Quantitative Trait Loci Sialic Acid Binding Immunoglobulin-like Lectins - genetics Stromelysin 2 Ventricle
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Zusammenfassung:	Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 participants from the BioFINDER study. Protein quantitative trait loci (pQTL) were identified as associations between genetic variants and proteins, with 176 pQTLs for 145 CSF proteins (P
ISSN:	1757-4676 1757-4684 1757-4684
DOI:	10.15252/emmm.202216359