Pathology of the Spleen in Hepatosplenic Schistosomiasis. Morphometric Evaluation and Extracellular Matrix Changes
Histological, ultrastructural, morphometric and immunohistochemical data obtained from the study of spleens removed by splenectomy from 34 patients with advanced hepatosplenic schistosomiasis revealed that the main alterations were congestive dilatation of the venous sinuses and diffuse thickening o...
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Veröffentlicht in: | Memórias do Instituto Oswaldo Cruz 1999-11, Vol.94 (6), p.815-822 |
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Zusammenfassung: | Histological, ultrastructural, morphometric and immunohistochemical
data obtained from the study of spleens removed by splenectomy from 34
patients with advanced hepatosplenic schistosomiasis revealed that the
main alterations were congestive dilatation of the venous sinuses and
diffuse thickening of the splenic cords. Splenic cord thickening was
due to an increase of its matrix components, especially type IV
collagen and laminin, with the conspicuous absence of interstitial
collagens, either of type I or type III. Deposition of interstitial
collagens (types I and III) occurred in scattered, small focal areas of
the red pulp, but in the outside of the walls of the venous sinuses, in
lymph follicles, marginal zone, in the vicinity of fibrous trabeculae
and in sidero-sclerotic nodules. However, fibrosis was not a prominent
change in schistosomal splenomegaly and thus the designation
"fibro-congestive splenomegaly" seems inadequate. Lymph follicles
exhibited variable degrees of atrophy, hyperplasia and fibrous
replacement, sometimes all of them seen in different follicles of the
same spleen and even in the same examined section. Changes in white
pulp did not seem to greatly contribute to increasing spleen size and
weight, when compared to the much more significant red pulp
enlargement. |
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ISSN: | 1678-8060 0074-0276 0074-0276 1678-8060 |
DOI: | 10.1590/S0074-02761999000600019 |