Protective effects of trimetazidine and coenzyme Q10 on cisplatin-induced cardiotoxicity by alleviating oxidative stress and mitochondrial dysfunction

The objective of this study was to investigate the effects of trimetazidine (TMZ) and coenzyme Q10 (CoQ10) on cisplatin-induced cardiotoxicity in rat cardiomyocytes. Rat cardiomyocytes were isolated and subjected to cisplatin (200 μM) treatment with and without TMZ (200 μM) and CoQ10 (200 mg/L) pret...

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Veröffentlicht in:	Anatolian journal of cardiology 2019-11, Vol.22 (5), p.232-239
1. Verfasser:	Zhao, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Apoptosis - drug effects Cardiotoxicity - prevention & control Cell Survival - drug effects Cisplatin - adverse effects cisplatin-induced cardiotoxicity coenzyme q10 Drug Therapy, Combination Mitochondria - drug effects mitochondrial dysfunction Myocytes, Cardiac - drug effects Original Investigation oxidative stress Rats trimetazidine Trimetazidine - pharmacology Ubiquinone - analogs & derivatives Ubiquinone - pharmacology
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Beschreibung
Zusammenfassung:	The objective of this study was to investigate the effects of trimetazidine (TMZ) and coenzyme Q10 (CoQ10) on cisplatin-induced cardiotoxicity in rat cardiomyocytes. Rat cardiomyocytes were isolated and subjected to cisplatin (200 μM) treatment with and without TMZ (200 μM) and CoQ10 (200 mg/L) pretreatment. The cell viability, apoptosis, oxidant and antioxidant indicators, and mitochondrial dysfunction were examined. TMZ or CoQ10 significantly attenuated cisplatin-induced cell viability inhibition (p
ISSN:	2149-2263 2149-2271 2149-2263
DOI:	10.14744/AnatolJCardiol.2019.83710