Non-Coding RNAs and Innate Immune Responses in Cancer

Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small inte...

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Veröffentlicht in:Biomedicines 2024-09, Vol.12 (9), p.2072
Hauptverfasser: Díaz, Carlos Romero, Hernández-Huerta, María Teresa, Mayoral, Laura Pérez-Campos, Villegas, Miriam Emily Avendaño, Zenteno, Edgar, Cruz, Margarito Martínez, Mayoral, Eduardo Pérez-Campos, Del Socorro Pina Canseco, María, Andrade, Gabriel Mayoral, Castellanos, Manuel Ángeles, Matías Salvador, José Manuel, Cruz Parada, Eli, Martínez Barras, Alexis, Cruz Fernández, Jaydi Nora, Scott-Algara, Daniel, Pérez-Campos, Eduardo
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Sprache:eng
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Zusammenfassung:Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), with a focus on cancer, innate immunity, and inflammation. We found that ncRNAs are closely related to innate immunity, epigenetics, chronic inflammation, and cancer and share properties such as inducibility, specificity, memory, and transfer. These similarities and interrelationships suggest that ncRNAs and modulators of trained immunity, together with the control of chronic inflammation, can be combined to develop novel therapeutic approaches for personalized cancer treatment. In conclusion, the close relationship between ncRNAs, the innate immune system, and inflammation highlights their importance in cancer pathways and their potential as targets for novel therapeutic strategies.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12092072