The

Background: Obese subjects with breast hypertrophy are suffering not only from cosmetic aspects but also negatively affecting the quality of their life so, the aim of this study was to evaluate the effect of weight reduction versus reduction-mammoplasty on pulmonary function parameters and serum-leptin level. Subjects and methods: Forty females with obesity and macromazia were enrolled into the study. They were classified into two groups, group (1) twenty females who were seeking reduction mammoplasty, and group (2) twenty females who refused surgery and were seeking diet-control regimen. Both groups were matched as regards age and body mass index (BMI). Pulmonary function parameters (FVC%, FEV1%, FEV1/FVC and PEFR%) and serum leptin level were measured before starting the intervention in both groups and after starting it by three months. Results: Reduction mammoplasty significantly increases FVC% with non-significant improvement regarding BMI and serum leptin level. On the other hand, diet control regimen improves FEV1%, FVC%, FEV1/FVC and PEFR% with a significant reduction of BMI and serum leptin levels. Conclusion: Reduction mammoplasty can play a role in improving restrictive pulmonary function parameters while diet control regimen has a more significant improvement in both obstructive and restrictive pulmonary function parameters and in the reduction of BMI and serum leptin level in obese subjects with macromazia.