Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon

This study was aimed at evaluating the performance of three CE-marked rapid diagnostic tests (RDTs): Multisure-HCV, First Response and Toyo ; for screening anti- HCV antibody using plasma samples. Overall, 200 plasma samples were used. Sensibility and specificity of these RDTs range from 71 to 99 an...

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Veröffentlicht in:	BMC research notes 2018-06, Vol.11 (1), p.352-352, Article 352
Hauptverfasser:	Fondjo, Clavel Landry Kouam, Ngoupo, Paul Alain Tagnouokam, Ngono, Laure, Plantier, Jean-Christophe, Njouom, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Cameroon Care and treatment Diagnosis Diagnostic tests Diagnostic Tests, Routine - methods HCV Hepatitis Hepatitis C Hepatitis C - blood Hepatitis C - diagnosis Hepatitis C Antibodies - blood HIV Human immunodeficiency virus Humans Immunoassay Immunoglobulins Infections Laboratories Mass Screening - methods Medical screening Methods Performance evaluation Plasma Rapid diagnostic test Reproducibility of Results Research Note Sensitivity and Specificity Statistical analysis
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Zusammenfassung:	This study was aimed at evaluating the performance of three CE-marked rapid diagnostic tests (RDTs): Multisure-HCV, First Response and Toyo ; for screening anti- HCV antibody using plasma samples. Overall, 200 plasma samples were used. Sensibility and specificity of these RDTs range from 71 to 99 and 78 to 100% respectively. Multisure scored a sensitivity at 99% (95% CI 97-100%) and First Response reached a specificity at 90% (95% CI 85-94.9%). Further studies should be conducted to establish an algorithm using these RTDs for the detection of HCV infection in Cameroon.
ISSN:	1756-0500 1756-0500
DOI:	10.1186/s13104-018-3465-8