Bone and joint health in children with severe hemophilia A: A single-center, prospective case-control study from North India

Poor bone and joint health, as evidenced by a reduction in bone mineral content and density (BMC, BMD) and progressive joint destruction, has been reported in hemophiliacs. Thirty children (4–17 y) with severe hemophilia A and 30 age and sex-matched healthy controls were included. Children with symp...

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Veröffentlicht in:Pediatric hematology oncology journal 2024-09, Vol.9 (3), p.176-179
Hauptverfasser: Khan, Zaibaish, Zaka-ur-Rab, Zeeba, Siddiqi, Sheelu Shafiq
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Sprache:eng
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Zusammenfassung:Poor bone and joint health, as evidenced by a reduction in bone mineral content and density (BMC, BMD) and progressive joint destruction, has been reported in hemophiliacs. Thirty children (4–17 y) with severe hemophilia A and 30 age and sex-matched healthy controls were included. Children with symptomatic hypocalcemia, rickets, recipients of drugs affecting BMD, and congenital skeletal malformation were excluded. Physical activity scoring (PAS), annualized bleeding rate (ABR), and annualized joint bleeding rate (AJBR) were determined in hemophiliacs. Joints were assessed by using Pettersson and Hemophilia Joint Health Score (HJHS) 2.1. BMC and BMD were estimated using a dual-energy X-ray absorptiometry (DEXA) scan. Serum vitamin D, calcium, phosphate, and alkaline phosphatase levels were estimated. BMD, serum vitamin D, and calcium were lower in hemophiliacs than in controls (p 
ISSN:2468-1245
2468-1245
DOI:10.1016/j.phoj.2024.05.001