Drug‐induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms due to diaminodiphenylsulfone during the treatment of pemphigus foliaceus

Laboratory examination identified leukocytosis (white blood cell 17,080/μl, neutrophils 88.0%, eosinophils 0.0%), atypical lymphocyte (1.0%), and liver dysfunction (aspartate aminotransferase 93 U/L, alanine aminotransferase 289 U/L). [...]genetic examination revealed that our patient held human leukocyte antigen (HLA)-B*13:01. DIHS/DRESS is a rare yet serious adverse drug reaction involving multiple organs. 1 Recently, several HLA alleles have been associated with sever drug eruptions. 2 HLA-B*13:01 was first described as a marker of susceptibility to DDS-induced DIHS/DRESS among patients with leprosy in Chinese populations. 3 Several investigators, then, reported the presence of HLA-B*13:01 among patients with DDS-induced DIHS/DRESS was not restricted to treat leprosy, but also other skin conditions. 4 To the best of our knowledge, this is the first Japanese case of the DIHS/DRESS due to DDS administered for PF patient with HLA-B*13:01.