Neuroprotective effect of hydroxy-α-sanshool against β-amyloid-induced damage in differentiated PC12 cells

Neuroprotective effect of hydroxy-α-sanshool against β-amyloid-induced damage in differentiated PC12 cells

In turn, oxidative stress could increase Aβ production. [...]antioxidant therapy is becoming a popular strategy for treating AD. [...]animal experiments are necessary to explore the effects and mechanisms of HαSS on AD. [...]the results from this study demonstrated that HαSS alleviated Aβ-induced in...

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Veröffentlicht in:Chinese medical journal 2023-09, Vol.136 (17), p.2140-2142
Hauptverfasser: Shan, Shufang, Zhou, Siquan, Ma, Guochen, Wang, Xiaoyu, Xiong, Jingyuan, Cheng, Guo
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Antioxidants
Apoptosis
Autophagy
Cell cycle
Correspondence
Flow cytometry
Investigations
Oxidation
Oxidative stress
Pathogenesis
Proteins
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Zusammenfassung:In turn, oxidative stress could increase Aβ production. [...]antioxidant therapy is becoming a popular strategy for treating AD. [...]animal experiments are necessary to explore the effects and mechanisms of HαSS on AD. [...]the results from this study demonstrated that HαSS alleviated Aβ-induced intracellular oxidative stress, inhibited autophagy, and reduced hyperphosphorylation of tau, supporting the neuroprotective effects of HαSS.
ISSN:2542-5641
0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002432