Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

Alzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression. To assess the association between sleep durat...

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Veröffentlicht in:	BMC geriatrics 2022-08, Vol.22 (1), p.638-10, Article 638
Hauptverfasser:	Yuan, Shiqi, Ma, Wen, Yang, Rui, Xu, Fengshuo, Han, Didi, Huang, Tao, Peng, MIn, Xu, Anding, Lyu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Alzheimer's disease (AD) Analysis Biobanks Biological Specimen Banks Cardiovascular disease Dementia Dementia disorders Development and progression Diabetes Education Environmental factors Ethnicity Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genomes Geriatrics Health risk assessment Health risks Heart attacks Humans Hypertension Influence Neurodegenerative diseases Older people Public health Risk factors Sleep Sleep - genetics Sleep duration Socioeconomic factors Statistical analysis Two Sample Mendelian randomization (MR) UK Biobank United Kingdom - epidemiology Variables
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Zusammenfassung:	Alzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression. To assess the association between sleep duration, genetic susceptibility, and AD. Based on 483,507 participants from the UK Biobank (UKB) with an average follow-up of 11.3 years, there was a non-linear relationship between AD incidence and sleep duration (P for non-linear
ISSN:	1471-2318 1471-2318
DOI:	10.1186/s12877-022-03298-8