多不饱和脂肪酸干预脱发症的研究现状及作用机制Research status of polyunsaturated fatty acid in the intervention of alopecia and its mechanism of action

脱发症是皮肤科常见疾病之一，发病率较高但临床治疗手段有限。大部分脱发症与毛囊周期的改变有关，而Omega-3及Omega-6多不饱和脂肪酸被证实通过促进或抑制毛囊细胞释放信号分子，从而促进毛囊生长、改善毛囊周期以及促进毛囊的再生。对多不饱和脂肪酸干预脱发症的研究现状及作用机制的国内外相关研究进行综述，期望能够为多不饱和脂肪酸对各类脱发症的治疗提供新思路及深入探讨脱发症的治疗方法及治疗机制提供借鉴，为利用现代分子生物技术改善脱发症提供理论依据。 Alopecia is one of the common diseases in dermatology, with a high incidence but limited clinical treatment. Most alopecia are associated with changes in hair follicle cycle, and Omega-3 and Omega-6 polyunsaturated fatty acids have been shown to promote or inhibit the release of signaling molecules by hair follicle cells to promote hair follicle growth, improve hair follicle cycle, and promote the regeneration of hair follicles. The research status of polyunsaturated fatty acids in the intervention of alopecia and the intervention mechanism were reviewed. It is expected to provide new ideas for the treatment of various types of alopecia by polyunsaturated fatty acids and to explore the treatment methods and mechanisms of alopecia,and to provide a theoretical basis for the improvement of alopecia by modern molecular biotechnology.