Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study

Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study

ObjectiveTo compare the severity of maternal infection and perinatal outcomes during periods in which wildtype, alpha variant, and delta variant of SARS-CoV-2 were dominant in the UK.DesignProspective cohort study.Setting194 obstetric units across the UK, during the following periods: between 1 Marc...

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Veröffentlicht in:BMJ medicine 2022-01, Vol.1 (1), p.e000053-e000053
Hauptverfasser: Vousden, Nicola, Ramakrishnan, Rema, Bunch, Kathryn, Morris, Eddie, Simpson, Nigel A B, Gale, Christopher, O'Brien, Patrick, Quigley, Maria, Brocklehurst, Peter, Kurinczuk, Jennifer J, Knight, Marian
Format: Artikel
Sprache:eng
Schlagworte:
COVID-19
neonatology
Original Research
pregnancy complications
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Zusammenfassung:ObjectiveTo compare the severity of maternal infection and perinatal outcomes during periods in which wildtype, alpha variant, and delta variant of SARS-CoV-2 were dominant in the UK.DesignProspective cohort study.Setting194 obstetric units across the UK, during the following periods: between 1 March and 30 November 2020 (wildtype dominance), between 1 December 2020 and 15 May 2021 (alpha variant dominance), and between 16 May and 31 October 2021 (delta variant dominance).Participants4436 pregnant women admitted to hospital with covid-19 related symptoms.Main outcome measuresModerate to severe maternal SARS-CoV-2 infection (indicated by any of the following: oxygen saturation
ISSN:2754-0413
2754-0413
DOI:10.1136/bmjmed-2021-000053