Case-finding for HPV vaccination eligibility within a dental office with concurrent development of a dialogue tool

•There is a concerning upward trend of HPV-associated oropharyngeal cancer in our society.•Dental professionals already screen for oral cancers and have a unique opportunity to help prevent oropharyngeal cancers by proactively discussing with their patients about cancer risk and by recommending HPV vaccination.•The design and evaluation of a case-finding method for HPV vaccine candidates in dental practices. A first for dentistry.•The development of a dialogue tool enabling discussions around HPV related Head and Neck Cancers within a dental office and prevention with vaccination. Human papillomavirus (HPV) immunization can prevent cancers, but uptake has been incomplete (and worse with the COVID-19 pandemic). Dental clinicians already screen for oral cancers, many of which are caused by HPV, and could identify vaccination candidates, but this requires a case-finding strategy. The purpose of this study was (1) to develop and test a case-finding approach to identify patients who were candidates for HPV vaccinations, (2) to test an HPV vaccination intervention by dental professionals on vaccination uptake. Design: Prospective, non-randomized feasibility case finding study with a 4-week enrollment period and a 6 week follow up period in general dental offices. Setting: Two general and non-commercial dentistry offices in Edmonton, Alberta Canada. Subjects: Consecutive scheduled (non-emergent) patients who met the Health Canada criteria for HPV vaccination: immunocompetent males and females aged 9–45 years and those who are immunocompromised. Consent for the discussion was obtained from each subject or parent. Intervention: Scheduled dental patients meeting the inclusion criteria were flagged by a research assistant who reviewed the appointment schedule each week for 4 weeks. For these subjects, dental clinicians (dentists and dental hygienists) used our Dental Dialogue Tool to discuss HPV vaccination and answer questions. Participating patients who consented to receive the HPV vaccine were given a prescription by the attending dentist and were directed to follow-up with a local pharmacy to have the vaccine administered. Each participant that was provided with an HPV prescription was contacted after 6 weeks to identify if they received the first dose of vaccine. Outcomes: Yield of our case-finding strategy and receipt of a patient’s first HPV vaccine dose during 6 weeks post vaccine prescription. Our case-finding strategy assessed 656 scheduled patients over 4