Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PM2.5 mass
Most fine ambient particulate matter (PM 2.5 )-based epidemiological models use globalized concentration-response (CR) functions assuming that the toxicity of PM 2.5 is solely mass-dependent without considering its chemical composition. Although oxidative potential (OP) has emerged as an alternate m...
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Veröffentlicht in: | Nature communications 2024-06, Vol.15 (1), p.5263-13, Article 5263 |
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Sprache: | eng |
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Zusammenfassung: | Most fine ambient particulate matter (PM
2.5
)-based epidemiological models use globalized concentration-response (CR) functions assuming that the toxicity of PM
2.5
is solely mass-dependent without considering its chemical composition. Although oxidative potential (OP) has emerged as an alternate metric of PM
2.5
toxicity, the association between PM
2.5
mass and OP on a large spatial extent has not been investigated. In this study, we evaluate this relationship using 385 PM
2.5
samples collected from 14 different sites across 4 different continents and using 5 different OP (and cytotoxicity) endpoints. Our results show that the relationship between PM
2.5
mass vs. OP (and cytotoxicity) is largely non-linear due to significant differences in the intrinsic toxicity, resulting from a spatially heterogeneous chemical composition of PM
2.5
. These results emphasize the need to develop localized CR functions incorporating other measures of PM
2.5
properties (e.g., OP) to better predict the PM
2.5
-attributed health burdens.
This study shows that the relationship between concentrations of ambient fine particulate matter (PM
2.5
) and its health effects may vary in different regions of the world due to significant spatial variations in the toxicities of PM
2.5
. |
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ISSN: | 2041-1723 2041-1723 |
DOI: | 10.1038/s41467-024-49649-4 |