Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

We report a case of a 64-year-old man who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anaemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease. Drug-induced TTP is a rare condition and di...

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Veröffentlicht in:European journal of case reports in internal medicine 2016, Vol.3 (5), p.000446-000446
Hauptverfasser: Lopez, Yanet Parodis, Gonzalez, Nery Sablon, Villalba, Noel Lorenzo, Galvan, Rafael Camacho, Perez, Jose Carlos Rodriguez
Format: Artikel
Sprache:eng
Schlagworte:
prasugrel
Thrombotic microangiopathy
thrombotic thrombocytopenic purpura
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Zusammenfassung:We report a case of a 64-year-old man who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anaemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease. Drug-induced TTP is a rare condition and difficult to diagnose.Decreased activity of ADAMTS13, unusual in drug-induced TTP, was present in this case.
ISSN:2284-2594
2284-2594
DOI:10.12890/2016_000446