NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation

•Graft-versus-host effects may lead to HIV-1 reactivation and cell death of infected pre-HCT CD4+ T cells.•Natural killer cell activation correlates with in vitro HIV-1 transcriptional activity in the setting of HCT.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2018-06, Vol.2 (12), p.1412-1416
Hauptverfasser:	Hogan, Louise E., Körner, Christian, Hobbs, Kristen, Simoneau, Camille R., Thanh, Cassandra, Gibson, Erica A., Palmer, Christine D., Pandit, Alisha, Marty, Francisco M., Kuritzkes, Daniel R., Jost, Stephanie, Ritz, Jerome, Henrich, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Cell Death Graft vs Host Disease - virology Hematopoietic Stem Cell Transplantation - methods HIV Infections - therapy HIV-1 - genetics Humans Killer Cells, Natural - immunology Killer Cells, Natural - virology Lymphocyte Activation Stimulus Report Transcription, Genetic Transplantation, Homologous Virus Activation
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Beschreibung
Zusammenfassung:	•Graft-versus-host effects may lead to HIV-1 reactivation and cell death of infected pre-HCT CD4+ T cells.•Natural killer cell activation correlates with in vitro HIV-1 transcriptional activity in the setting of HCT.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2018016329